Osteo Bi-Flex Triple Strength Caplets are a revolutionary formula containing Glucosamine Chondroitin and MSM as well as the unique internationally patent-pending ingredient 5-Loxin Advanced. Taking 5-Loxin Advanced shows improvement in joint comfort within 7 days.** 5-Loxin Advanced Glucosamine and the proprietary blend Joint Shield create a dynamic combination to promote mobility renew cartilage maintain healthy connective tissue. * Just 2 easy-to-swallow capsules help protect cartilage and help with pesky flare-ups while renewing cellular components within joints.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose treat cure or prevent any disease. **This statement is based on two human studies of 5-Loxin Advanced using subjective measures in which participants rate their joint health. In these studies further improvement was observed after 7 days including in the biomarker analysis.